SEQUENCE ANALYSIS AND STRUCTURAL PREDICTIONS OF LIPID TRANSFER BRIDGES IN THE REPEATING BETA GROOVE (RBG) SUPERFAMILY REVEAL PAST AND PRESENT DOMAIN VARIATIONS AFFECTING FORM, FUNCTION AND INTERACTIONS OF VPS13, ATG2, SHIP164, HOBBIT AND TWEEK

Lipid transfer between organelles requires proteins that shield the hydrophobic portions of lipids as they cross the cytoplasm.In the last decade a new structural form of lipid transfer protein (LTP) has been found: long hydrophobic grooves made of beta-sheet that bridge between organelles at membrane contact sites.Eukaryotes have five families of

Polycomb Lunchbag Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression.Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs.In the absence

Background: In patients with significant Citrus Squeezers mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (M-TEER), assessment of mitral valve (MV) anatomy is essential.While transthoracic echocardiography (TTE) is the initial diagnostic tool, transesophageal echocardiography (TOE) provides better anatomical details.The study

OBJECTIVE: To estimate the cost of scaling up childhood immunization services required to reach Training Pants the WHO-UNICEF Global Immunization Vision and Strategy (GIVS) goal of reducing mortality due to vaccine-preventable diseases by two-thirds by 2015.METHODS: A model was developed to estimate the total cost of reaching GIVS goals by 2015 in